Artists like Los de la Nazza

R.K.M & Ken-Y is a Puerto Rican reggaeton duo formed in 2003 by José Nieves (R.K.M) and Kenny Vázquez (Ken-Y). The artists are renowned in the Latin music world for being the first to successfully fuse mainstream pop music with the reggaeton street rhythms of Puerto Rico and expose the style to a wide international audience. The sound introduced by R.K.M & Ken-Y would go on to inspire the pop reggaeton songs of successful acts such as CNCO, J Balvin, and Maluma. The duo had a very successful career with the Spanish-speaking audience of Latin America, the United States, and Spain until their separation in 2013. In June 2017, the duo announced their official return by Pina Records. In mid-2021 the Duo confirmed that they are on hiatus and are currently working on their solo projects.

Bryan Robert Rohena Pérez, known professionally as Bryant Myers, is a Puerto Rican rapper, singer and songwriter. Rohena was born in Loma Alta, Puerto Rico. He began sampling and making his own songs in 2013 and launched them on social media via his SoundCloud, Instagram and YouTube accounts. He is best known for his single "Esclava", which gained him popularity in his hometown.

Bryan Cancel Santiago, better known by his stage name Brytiago, is a Puerto Rican singer and songwriter. He was born in Carolina, Puerto Rico. He started his career in 2014, at age 21. In 2016, when he was 23 years old, he joined El Cartel Records, Daddy Yankee's record label. He has released several songs such as "Bebé", "Lonely", "Punto G", "High", "Abuso", which have all achieved moderate success in Latin America. In 2018, he released "Bipolar", along with Ozuna and Chris Jedi. The single was a success, and peaked at No. 17 on the Billboard Hot Latin Songs chart.

Osvaldo Elías Castro Hernández, better known by the stage name Darell, is a Puerto Rican rapper and songwriter. Born in Puerto Rico, he moved to New York. He is signed to White Lion Records and Sony Music Latin.

Julio Voltio is a Puerto Rican former rapper. An early pioneer of reggaetón—a modern genre of Latin music originating in Puerto Rico, with sonic roots in Jamaican dancehall and American hip hop—Voltio officially retired from the music industry in 2014, having converted to Evangelicalism.

Trébol Clan is a Puerto Rican reggaeton musical group, introduced in the genre by DJ Joe. Formed by Hector Pagan "Periquito/Trebol", Omar "Plomo" and Berto "El Original", Trébol Clan has been featured in Don Omar's The Last Don and Los Bandoleros, Luny Tunes's Mas Flow 2, and have released one CD in the genre named Los Bacatranes. When they had their label, they released the mixtape Los Reyes de la Lenta: The Comeback (2008).