Artists like Vico C

Julio Voltio is a Puerto Rican former rapper. An early pioneer of reggaetón—a modern genre of Latin music originating in Puerto Rico, with sonic roots in Jamaican dancehall and American hip hop—Voltio officially retired from the music industry in 2014, having converted to Evangelicalism.

Trébol Clan is a Puerto Rican reggaeton musical group, introduced in the genre by DJ Joe. Formed by Hector Pagan "Periquito/Trebol", Omar "Plomo" and Berto "El Original", Trébol Clan has been featured in Don Omar's The Last Don and Los Bandoleros, Luny Tunes's Mas Flow 2, and have released one CD in the genre named Los Bacatranes. When they had their label, they released the mixtape Los Reyes de la Lenta: The Comeback (2008).

Alexis & Fido, a.k.a. Los Pitbulls, Los Reyes del Perreo, are a reggaeton duo from Puerto Rico. They are CEOs and co-founders of Wild Dogz Music. In 2008, Sobrenatural was nominated for Album Urbano. In 2012, "Energía" was nominated for Canción Urbana. In 2013, "Rompe la Cintura" was nominated for – Interpretación Urbana. Nominated for the 2014 awards, "Álbum Urbano" with La Esencia.

Control Machete is a Mexican hip-hop group from Monterrey, Nuevo León. Its members are Fermín IV, Patricio "Pato Machete" Chapa Elizalde, and Toy Kenobi.

David Sánchez Badillo, known professionally as Tempo, is a Puerto Rican rapper and songwriter. He was the leading figure in the reggaeton scene from the late 1990s until his arrest in 2002. He was released in 2013 after spending 11 years in prison. Although Tempo had success during the emergence of reggaeton, his popularity faded following his imprisonment; he is nowadays regarded as a controversial figure within the genre.

R.K.M & Ken-Y is a Puerto Rican reggaeton duo formed in 2003 by José Nieves (R.K.M) and Kenny Vázquez (Ken-Y). The artists are renowned in the Latin music world for being the first to successfully fuse mainstream pop music with the reggaeton street rhythms of Puerto Rico and expose the style to a wide international audience. The sound introduced by R.K.M & Ken-Y would go on to inspire the pop reggaeton songs of successful acts such as CNCO, J Balvin, and Maluma. The duo had a very successful career with the Spanish-speaking audience of Latin America, the United States, and Spain until their separation in 2013. In June 2017, the duo announced their official return by Pina Records. In mid-2021 the Duo confirmed that they are on hiatus and are currently working on their solo projects.

Wisin & Yandel were a Puerto Rican reggaeton duo consisting of Wisin and Yandel. They started their career in 1998 and stayed together until 2023, winning several awards including a Grammy Award in 2009. They became the first reggaeton artists to win one. In late 2013, they announced they would take a pause in their career as a duo, after their Líderes Tour. In a 2014 interview with People en Español, Yandel confirmed that the group would not be disbanding. In February 2018, following a five-year hiatus, the duo announced they would be reuniting, and were set to embark on a world tour, as well as release new music. They sold over 15 million records.

Orishas are a Cuban hip hop group from Havana, Cuba, founded in 1999. The group was first called "Amenaza", "threat" or "menace" in Spanish, and appealed to the Cuban youth. The choice of this name for the hip hop group is a way of creating a direct link between this band and the African diaspora. The group is based in France where they made a deal with a record company, although they visit Cuba frequently. In 1999 Fidel Castro threw a party for them and had a meeting with all the musicians. It was the first time the Cuban government showed support for hip hop music. The group was and still is popular in Europe and Latin America. Yotuel Romero and Ruzzo Medina, who moved from Havana to Paris as part of an international studies program, joined Roldán González and Flaco-Pro to form the band in 1999. Their work is influenced by the hip hop movement as well as Cuban and other Latin rhythms. As of November 2024, they had produced a total of five studio albums and a greatest hits album; their latest album is Gourmet. In 2009 they participated in the concert Paz Sin Fronteras II in Plaza de la Revolución, Havana, Cuba. Orishas reunited to record new material in 2016.

Bryan Robert Rohena Pérez, known professionally as Bryant Myers, is a Puerto Rican rapper, singer and songwriter. Rohena was born in Loma Alta, Puerto Rico. He began sampling and making his own songs in 2013 and launched them on social media via his SoundCloud, Instagram and YouTube accounts. He is best known for his single "Esclava", which gained him popularity in his hometown.