Artists like Big Walter Horton

Slim Harpo was an American blues musician, a leading exponent of the swamp blues style, and "one of the most commercially successful blues artists of his day". He played guitar and was a master of the blues harmonica, known in blues circles as a "harp". His most successful and influential recordings included "I'm a King Bee" (1957), "Rainin' in My Heart" (1961), and "Baby Scratch My Back" (1966), which reached number one on Billboard's R&B chart and number 16 on its broader Hot 100 singles chart.

Elmore James was an American blues guitarist, singer, songwriter, and bandleader. Noted for his use of loud amplification and his stirring voice, James was inducted into the Rock and Roll Hall of Fame in 1992. His slide guitar technique earned him the nickname "King of the Slide Guitar".

Earl Zebedee Hooker was a Chicago blues guitarist known for his slide guitar playing. Considered a "musician's musician", he performed with blues artists such as Sonny Boy Williamson II, Junior Wells, and John Lee Hooker and fronted his own bands. An early player of the electric guitar, Hooker was influenced by the modern urban styles of T-Bone Walker and Robert Nighthawk. He recorded several singles and albums as a bandleader and with other well-known artists. His "Blue Guitar", a slide guitar instrumental single, was popular in the Chicago area and was later overdubbed with vocals by Muddy Waters as "You Shook Me".

The Paul Butterfield Blues Band was an American blues and blues-rock band from Chicago. Formed in the summer of 1963, the group originally featured eponymous vocalist and harmonicist Paul Butterfield, guitarist Elvin Bishop, bassist Jerome Arnold, and drummer Sam Lay. The band added guitarist Mike Bloomfield and keyboardist Mark Naftalin before recording their self-titled debut album, which was released in October 1965. The founding sextet were inducted into the Rock and Roll Hall of Fame in 2015, along with Billy Davenport, their drummer on their second album, East-West.

J. B. Lenoir was an American blues guitarist and singer-songwriter, active in the Chicago blues scene in the 1950s and 1960s. In The Encyclopedia of Popular Music he is described as both an "extrovert R&B man in the leopard-skin jacket who chanted infectious trifles" and a "thoughtful and intelligent writer of starkly honest blues songs."