Artists like La Factoria

Eduardo Mosquera, better known by his stage name Eddy Lover, is a Panamanian reggaeton and Spanish reggae singer and songwriter. Lover rose to international fame with his guest appearance on La Factoría's 2006 smash hit "Perdóname".

Trébol Clan is a Puerto Rican reggaeton musical group, introduced in the genre by DJ Joe. Formed by Hector Pagan "Periquito/Trebol", Omar "Plomo" and Berto "El Original", Trébol Clan has been featured in Don Omar's The Last Don and Los Bandoleros, Luny Tunes's Mas Flow 2, and have released one CD in the genre named Los Bacatranes. When they had their label, they released the mixtape Los Reyes de la Lenta: The Comeback (2008).

R.K.M & Ken-Y is a Puerto Rican reggaeton duo formed in 2003 by José Nieves (R.K.M) and Kenny Vázquez (Ken-Y). The artists are renowned in the Latin music world for being the first to successfully fuse mainstream pop music with the reggaeton street rhythms of Puerto Rico and expose the style to a wide international audience. The sound introduced by R.K.M & Ken-Y would go on to inspire the pop reggaeton songs of successful acts such as CNCO, J Balvin, and Maluma. The duo had a very successful career with the Spanish-speaking audience of Latin America, the United States, and Spain until their separation in 2013. In June 2017, the duo announced their official return by Pina Records. In mid-2021 the Duo confirmed that they are on hiatus and are currently working on their solo projects.

Alexis & Fido, a.k.a. Los Pitbulls, Los Reyes del Perreo, are a reggaeton duo from Puerto Rico. They are CEOs and co-founders of Wild Dogz Music. In 2008, Sobrenatural was nominated for Album Urbano. In 2012, "Energía" was nominated for Canción Urbana. In 2013, "Rompe la Cintura" was nominated for – Interpretación Urbana. Nominated for the 2014 awards, "Álbum Urbano" with La Esencia.

Edgardo Antonio Miranda Beiró, better known as Joey Montana, is a Panamanian reggaeton singer. He is best known for the hit singles "Picky" and his collaboration with Sebastián Yatra, "Suena El Dembow".

Félix Danilo Gómez Bosquez, known by his stage name Flex, is a Panamanian reggaeton singer. He originally adopted the name Nigga after being told by another Panamanian artist that he "sings like a black guy from Jamaica." Before releasing his debut album in the United States in 2010, Flex removed references to his nickname in songs, and his albums were reissued with the new name, "Flex".

Wisin & Yandel were a Puerto Rican reggaeton duo consisting of Wisin and Yandel. They started their career in 1998 and stayed together until 2023, winning several awards including a Grammy Award in 2009. They became the first reggaeton artists to win one. In late 2013, they announced they would take a pause in their career as a duo, after their Líderes Tour. In a 2014 interview with People en Español, Yandel confirmed that the group would not be disbanding. In February 2018, following a five-year hiatus, the duo announced they would be reuniting, and were set to embark on a world tour, as well as release new music. They sold over 15 million records.

Bryan David Castro Sosa, known professionally as Ryan Castro, is a Colombian rapper, singer and songwriter. He achieved worldwide recognition for his songs "Quema", "Jordan", "Mujeriego", and "Monastery".

Miguel Ángel Durán Jr. known by his stage name as Fuego ("fire"), is an American singer and founder of Fireboy Music. He is currently signed to Lionfish Entertainment.