Artists like Niko King

Iván Vladimir Banista, better known as El Roockie or The Roockie is a Panamanian reggae recording artist, currently signed to Luny Tunes' Mas Flow Inc. He is widely praised for his powerful and delivering lyrics, earning him the nickname 'King of Lyrics' and 'Maquina de Lirica'.

Chapa C is a Cuban reggaeton group led by Maikel Romera Alonso known by his stage name D.J. Sam. Initially the group was formed by Maikel Romera Alonso, Idilio Márquez Amores (Rhagga), Norge Rafael Hadfen and Julio Esteban Haynes Pupo (Julito). Eventually El Pollo, Julito and Rhagga left the group, however, D.J. Sam decided to carry on with the project with former singer of TecnoCaribe Cuban group, Maurice Luis Montagne Maceiros, known as El Classico.

Edgardo Antonio Miranda Beiró, better known as Joey Montana, is a Panamanian reggaeton singer. He is best known for the hit singles "Picky" and his collaboration with Sebastián Yatra, "Suena El Dembow".

Eduardo Mosquera, better known by his stage name Eddy Lover, is a Panamanian reggaeton and Spanish reggae singer and songwriter. Lover rose to international fame with his guest appearance on La Factoría's 2006 smash hit "Perdóname".

Los Rakas are a Grammy Award–nominated bilingual hip hop group based in Oakland, California, consisting of Panamanian cousins Raka Rich and Raka Dun. Their style consists of a mixture of hip hop influences with reggaeton, reggae, and dancehall. One of their notable collaborations includes the American new Wave band Blondie on their 2014 studio album Ghosts of Download, where they appeared as a featured artist on the track "I Screwed Up". Other collaborations include music with: E-40, Nina Sky, Baby Bash, Berner, Keak Da Sneak, Kool John, San Quinn, Show Banga, X-raided, Goapale, IAMSU!, Baby Gas, & Atropolis. As of 04/20/22 Los Rakas have partnered with Camabis to release their own cannabis strain "Raka Exotic". They are currently working on a new studio album expected to drop between late 2022 and early 2023.

Félix Danilo Gómez Bosquez, known by his stage name Flex, is a Panamanian reggaeton singer. He originally adopted the name Nigga after being told by another Panamanian artist that he "sings like a black guy from Jamaica." Before releasing his debut album in the United States in 2010, Flex removed references to his nickname in songs, and his albums were reissued with the new name, "Flex".

Magnate & Valentino were a Puerto Rican reggaeton duo made up of Ramón del Robledo Nuñez Oliviera known as Magnate and Peter González Torres known as Valentino. The duo were initially called Los Nene before adopting the name Magnate y Valentino. They were among the first duos to include ballads and romantic songs in the discography. Having debuted in 1998 in an artists compilation album The Warriors 2: Batalla En Dos Tiempos, the two continued to be featured in other compilations like Tha Cream 4, 9 Plagas 2, The Flow 2 and The show en la Feria. However it was with Rompiendo el Hielo their debut album in 2002 that they were highlighted cooperating with Héctor & Tito in "Gata Celosa" and with Nicky Jam in "Quiero que hagas mujer". "Te Buscaré" arranged by Alejandro Montalván and Eduardo Reyes, was a huge hit. The follow-up albums were Sin Límite (2004), and Quimica Perfecta (2009). The duo also collaborated with Don Omar in the hit "Dile a Ella". Imparables became the duo's last album together in 2013. Soon after, the duo separated and each continued with a solo career.

David Luciano Acosta, known professionally as Baby Ranks, is a Puerto Rican and Dominican reggaeton artist. He has co-billing on the Luny Tunes album Mas Flow 2, and sings on multiple tracks including the single "Mayor Que Yo". The album ranked #5 on the Billboard year-end Latin Album Chart, #7 on the year-end Tropical Album Chart, and #9 on the Reggae Album Chart, for the year 2005. "Mayor Que Yo" won Reggaeton Song of the Year at the 2006 Latin Billboard Music Awards.