Artists like El Chombo

Trébol Clan is a Puerto Rican reggaeton musical group, introduced in the genre by DJ Joe. Formed by Hector Pagan "Periquito/Trebol", Omar "Plomo" and Berto "El Original", Trébol Clan has been featured in Don Omar's The Last Don and Los Bandoleros, Luny Tunes's Mas Flow 2, and have released one CD in the genre named Los Bacatranes. When they had their label, they released the mixtape Los Reyes de la Lenta: The Comeback (2008).

Félix Danilo Gómez Bosquez, known by his stage name Flex, is a Panamanian reggaeton singer. He originally adopted the name Nigga after being told by another Panamanian artist that he "sings like a black guy from Jamaica." Before releasing his debut album in the United States in 2010, Flex removed references to his nickname in songs, and his albums were reissued with the new name, "Flex".

Edgardo Antonio Miranda Beiró, better known as Joey Montana, is a Panamanian reggaeton singer. He is best known for the hit singles "Picky" and his collaboration with Sebastián Yatra, "Suena El Dembow".

Wisin & Yandel were a Puerto Rican reggaeton duo consisting of Wisin and Yandel. They started their career in 1998 and stayed together until 2023, winning several awards including a Grammy Award in 2009. They became the first reggaeton artists to win one. In late 2013, they announced they would take a pause in their career as a duo, after their Líderes Tour. In a 2014 interview with People en Español, Yandel confirmed that the group would not be disbanding. In February 2018, following a five-year hiatus, the duo announced they would be reuniting, and were set to embark on a world tour, as well as release new music. They sold over 15 million records.

Alexis & Fido, a.k.a. Los Pitbulls, Los Reyes del Perreo, are a reggaeton duo from Puerto Rico. They are CEOs and co-founders of Wild Dogz Music. In 2008, Sobrenatural was nominated for Album Urbano. In 2012, "Energía" was nominated for Canción Urbana. In 2013, "Rompe la Cintura" was nominated for – Interpretación Urbana. Nominated for the 2014 awards, "Álbum Urbano" with La Esencia.