Artists like Big Maceo Merriweather

Slim Harpo was an American blues musician, a leading exponent of the swamp blues style, and "one of the most commercially successful blues artists of his day". He played guitar and was a master of the blues harmonica, known in blues circles as a "harp". His most successful and influential recordings included "I'm a King Bee" (1957), "Rainin' in My Heart" (1961), and "Baby Scratch My Back" (1966), which reached number one on Billboard's R&B chart and number 16 on its broader Hot 100 singles chart.

Arthur Blake, known as Blind Blake, was an American blues and ragtime singer and guitarist. He is known for recordings he made for Paramount Records between 1926 and 1932.

Earl Zebedee Hooker was a Chicago blues guitarist known for his slide guitar playing. Considered a "musician's musician", he performed with blues artists such as Sonny Boy Williamson II, Junior Wells, and John Lee Hooker and fronted his own bands. An early player of the electric guitar, Hooker was influenced by the modern urban styles of T-Bone Walker and Robert Nighthawk. He recorded several singles and albums as a bandleader and with other well-known artists. His "Blue Guitar", a slide guitar instrumental single, was popular in the Chicago area and was later overdubbed with vocals by Muddy Waters as "You Shook Me".

Fred McDowell, known by his stage name Mississippi Fred McDowell, was an American singer-songwriter and guitarist of hill country blues music.

Elmore James was an American blues guitarist, singer, songwriter, and bandleader. Noted for his use of loud amplification and his stirring voice, James was inducted into the Rock and Roll Hall of Fame in 1992. His slide guitar technique earned him the nickname "King of the Slide Guitar".

J. B. Lenoir was an American blues guitarist and singer-songwriter, active in the Chicago blues scene in the 1950s and 1960s. In The Encyclopedia of Popular Music he is described as both an "extrovert R&B man in the leopard-skin jacket who chanted infectious trifles" and a "thoughtful and intelligent writer of starkly honest blues songs."

John Mayall & the Bluesbreakers were an English blues rock band led by multi-instrumentalist, singer and songwriter John Mayall. The band has been influential as an incubator for British rock and blues musicians. Many of the best known bands to come out of Britain in the 1960s and 1970s had members that came through the Bluesbreakers at one time, forming the foundation of British blues music that is still played heavily on classic rock radio. Among those with a tenure in the Bluesbreakers are guitarists Eric Clapton, Peter Green and Mick Taylor, bassists John McVie, Jack Bruce and Tony Reeves, drummers Hughie Flint, Aynsley Dunbar, Mick Fleetwood and Jon Hiseman, and numerous others.

Percy Mayfield was an American rhythm and blues singer with a smooth vocal style. He was also a songwriter, known for the songs "Please Send Me Someone to Love" and "Hit the Road Jack", the latter being a song first recorded by Ray Charles.

Nehemiah Curtis "Skip" James was an American Delta blues singer, guitarist, pianist and songwriter. AllMusic stated: "Coupling an oddball guitar tuning set against eerie, falsetto vocals, James' early recordings could make the hair stand up on the back of your neck."

Leroy Carr was an American blues singer, songwriter and pianist who developed a laid-back, crooning technique and whose popularity and style influenced such artists as Nat King Cole and Ray Charles. Music historian Elijah Wald has called him "the most influential male blues singer and songwriter of the first half of the 20th century". He first became famous for "How Long, How Long Blues", his debut recording released by Vocalion Records in 1928.

Huddie William Ledbetter, better known by the stage name Lead Belly, was an American folk and blues singer notable for his strong vocals, virtuosity on the twelve-string guitar, and the folk standards he introduced, including his renditions of "In the Pines", "Pick a Bale of Cotton", "Goodnight, Irene", "Black Betty", "Midnight Special", "Cotton Fields", and "Boll Weevil".

Robert Calvin Bland, known professionally as Bobby "Blue" Bland, was an American blues singer. Bland developed a sound that mixed gospel with the blues and R&B. He was described as "among the great storytellers of blues and soul music... [who] created tempestuous arias of love, betrayal and resignation, set against roiling, dramatic orchestrations, and left the listener drained but awed." The inspiration behind his unique style was a Detroit Preacher, CL Franklin, because Bland studied his sermons. He was sometimes referred to as the "Lion of the Blues" and as the "Sinatra of the Blues". His music was influenced by Nat King Cole.